Market Intelligence for Mild To Moderate Plaque Psoriasis

Executive Summary

Emerging therapeutic interventions including INBRX-109, TIBSOVO (ivosidenib), and additional novel compounds are anticipated to drive significant expansion in the Mild To Moderate Plaque Psoriasis Market throughout the forecast period.

DelveInsight presents the comprehensive "Mild To Moderate Plaque Psoriasis - Market Intelligence, Epidemiological Analysis, and Market Projections-2032" report, delivering extensive understanding of Mild To Moderate Plaque Psoriasis pathology, historical and projected epidemiological trends, and market dynamics across the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom), and Japan.

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Key Market Intelligence Highlights

Critical Market Statistics:

• The Mild-to-Moderate Plaque Psoriasis Market demonstrates substantial projected growth with significant CAGR during the forecast period (2023-2032)
• Regulatory Milestone (2024): China granted approval for Jinlixi, a monoclonal antibody targeting interleukin-17A neutralization, for moderate-to-severe plaque psoriasis treatment in adults
• FDA Approval (September 2022): Sotyktu received authorization as an oral tyrosine kinase 2 (TYK2) inhibitor, introducing innovative therapeutic mechanisms for moderate-to-severe plaque psoriasis management
• Biosimilar Approvals (December 2024): FDA approved ustekinumab-kfce (Yesintek) and ustekinumab-stba (Steqeyma), expanding treatment accessibility for plaque psoriasis patients
• Clinical Success: Johnson Johnson's oral medication icotrokinra achieved primary endpoints in late-stage trials for moderate-to-severe plaque psoriasis, demonstrating substantial skin clearance in 64.7% of patients within 16 weeks
• Indication Expansion (December 2021): FDA broadened Otezla's therapeutic scope to encompass adult patients with plaque psoriasis across all severity levels—mild, moderate, and severe—establishing it as the first oral treatment approved for such comprehensive patient populations
• Leading pharmaceutical enterprises including AbbVie, Pfizer, Johnson Johnson (JJ), Bristol-Myers Squibb, UCB Pharma, Amgen, Novartis, Eli Lilly, Sun Pharma, Dermavant, Dr. Reddy's Laboratories, Arcutis Biotherapeutics, and others are actively advancing mild-to-moderate plaque psoriasis therapeutic development
• Approximately 78% of psoriasis patients present with mild to moderate disease manifestations (≤10% body surface area involvement), with mild cases (≤3% BSA) representing 50% of all instances. Conversely, only 2% of patients experience extensive psoriasis affecting more than 50% of body surface area
• Epidemiological Data: A 2021 U.S. cross-sectional online survey by Gupta et al. encompassed 175 patients with mild-to-moderate plaque psoriasis, revealing 67.4% female prevalence, median age of 55 years, and average disease duration of 10.8 years since diagnosis
• Promising pipeline therapeutics across various development stages include Otezla, SGX302, AKP02/AKVANO, and additional investigational compounds

Report Value Proposition

Key Benefits of Market Analysis:

• Comprehensive Coverage: Detailed epidemiological overview and market insights across 7MM (United States, EU5 (Germany, Spain, France, Italy, UK) Japan)
• Therapeutic Landscape: Intelligence on current and emerging therapeutic interventions
• Global Market Perspective: Historical and forecasted market analysis covering drug penetration in 7MM
• Strategic Intelligence: Business strategy development support through trend analysis and market drivers identification

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Clinical Overview of Mild To Moderate Plaque Psoriasis

Psoriasis represents a chronic, immune-mediated dermatological disorder that accelerates skin cell regeneration cycles, causing cellular multiplication rates up to 10 times faster than normal physiological processes. This pathophysiological acceleration results in thick, erythematous patches with characteristic silvery scaling, frequently accompanied by intense pruritus. These lesions commonly manifest on elbows, knees, scalp, lower back, face, palms, and soles, while potentially affecting nails, oral mucosa, and additional anatomical sites.

Plaque psoriasis, the predominant clinical variant, accounts for approximately 80% of all psoriasis cases. Diagnostic evaluation involves comprehensive examination of skin, scalp, and nail characteristics for pathognomonic signs. Selected cases require biopsy procedures, where dermatopathologists perform microscopic analysis of skin cells to confirm psoriatic diagnosis. Dermatologists typically employ punch biopsy techniques for this assessment.

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Treatment Market Landscape

Current Treatment Protocols:

The American Academy of Dermatology (AAD) clinical guidelines recommend initiating localized mild-to-moderate plaque psoriasis management with patient education and topical corticosteroids, administered independently or in combination with coal tar or calcipotriene.

Secondary treatment options include anthralin or tazarotene, utilized individually or with corticosteroids, when initial therapeutic approaches prove ineffective or demonstrate diminishing efficacy over time.

For challenging disease control scenarios or widespread psoriasis manifestations, phototherapy—with or without adjunctive medications such as psoralen or retinoids—may be necessary.

Market Outlook and Therapeutic Landscape

Treatment Modalities:

Topical therapies serve as first-line interventions for localized plaque psoriasis, while phototherapy remains extensively utilized for mild-to-moderate cases. Established light-based treatments encompass whole-body or targeted UVB (broad and narrow band), photochemotherapy (PUVA), home phototherapy, and LASER applications.

Systemic therapeutic options include acitretin, methotrexate, cyclosporine, tacrolimus, hydroxyurea, 6-thioguanine, mycophenolate, fumaric acid esters, apremilast, and biological agents. Among biologics, etanercept, adalimumab, infliximab, secukinumab, ustekinumab, tildrakizumab, and ixekizumab maintain approval for plaque psoriasis treatment.

According to DelveInsight analysis, the Mild-to-Moderate Plaque Psoriasis Market across 7MM is projected to experience substantial transformation during the 2019-2032 study period.

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Pipeline and Marketed Therapeutics

Emerging Therapies:

• SGX302: Soligenix
• AKP02/AKVANO: Lipidor AB

Marketed Therapeutics:

• Otezla: Amgen

Report Scope and Coverage

Study Parameters:

• Study Period: 2019-2032
• Geographic Coverage: 7MM [United States, EU5 (Germany, France, Italy, Spain, United Kingdom), and Japan]
• Key Industry Players: AbbVie, Pfizer, Johnson Johnson (JJ), Bristol-Myers Squibb, UCB Pharma, Amgen, Novartis, Eli Lilly, Sun Pharma, Dermavant, Dr. Reddy's Laboratories, Arcutis Biotherapeutics, and others
• Key Therapeutic Interventions: Otezla, SGX302, AKP02/AKVANO, and others

Analytical Framework:

• Therapeutic Assessment: Current marketed and emerging therapeutic evaluation
• Market Dynamics: Market drivers and barriers analysis
• Competitive Intelligence: SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies
• Comprehensive Analysis: Unmet needs, KOL perspectives, analyst viewpoints, market access and reimbursement

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Report Structure

Table of Contents:

1. Introduction and Methodology
2. Executive Summary
3. SWOT Analysis
4. Patient Share Overview
5. Market Overview
6. Disease Background and Clinical Overview
7. Epidemiology and Patient Population
8. Country-Specific Patient Demographics
9. Current Treatment and Medical Practices
10. Unmet Medical Needs
11. Emerging Therapeutic Interventions
12. Market Outlook and Projections
13. Country-Specific Market Analysis (2019-2032)
14. Market Access and Reimbursement
15. Market Drivers
16. Market Barriers
17. Appendices
18. Research Methodology
19. DelveInsight Capabilities
20. Disclaimer
21. About DelveInsight

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About DelveInsight

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