Influenza A clinical and preclinical studies, key players, treatment evaluation, emerging therapies, treatment algorithm

Influenza A Overview:

Influenza vaccines play an important role in preventing seasonal influenza, which is caused by the rapidly mutating influenza virus. They are usually updated annually to target the most prevalent strains, including both influenza A and influenza B, and help the immune system produce antibodies to recognize and fight the virus. This helps reduce the severity of the illness and minimizes complications such as pneumonia, hospitalization, and death. They come in multiple forms, including inactivated (influenza vaccine) and live-attenuated (nasal spray), and are tailored for different age groups and health conditions.

Mass vaccination is essential for public health, especially for vulnerable populations such as young children, the elderly, pregnant women, and individuals with chronic medical conditions such as asthma or heart disease. Vaccines reduce the strain on healthcare systems by reducing influenza-related hospitalizations and doctor visits. Vaccine effectiveness varies from year to year, but studies consistently show a significant reduction in severe influenza cases. Leading health organizations such as the WHO and CDC advocate annual influenza vaccination as the most effective measure to prevent epidemics and protect community health.

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DelveInsight's "Influenza A Pipeline Insights 2025" report provides a comprehensive analysis of the ongoing clinical developments and growth prospects in the Influenza A therapeutics market.

Key Takeaways from the Influenza A Pipeline Report:

The report highlights an active pipeline with leading companies developing innovative therapeutics for the treatment of Influenza A.

Major companies, including Cidara Therapeutics, SAB Biotherapeutics, FluGen, Moderna, Vir Biotechnology, and Vaxart, are evaluating new drugs to strengthen the influenza A treatment landscape.

Promising pipeline therapies at various stages of development include VIR-2482, SAB-176, CD388, FLUZONE QUADRIVALENT, RAPIVAB (peramivir injection), and XOFLUZA (baloxavir marboxil).

Recent advances in the influenza A pipeline:

September 2025: FDA approves self- or caregiver-administered FluMist. The nasal spray vaccine, effective against influenza A and B, is now available to people ages 2 to 49, providing convenient flu prevention.

mRNA-based influenza vaccines are progressing, with Moderna's mRNA-1010 vaccine meeting all primary immunogenicity endpoints in a Phase 3 trial and regulatory submission planned for 2025.

Pfizer and BioNTech are developing a quadrivalent mRNA influenza vaccine that has demonstrated strong immune responses in early-stage studies.

Influenza A Pipeline Analysis

This report provides insights into:

Major companies are developing treatments for influenza A.

Therapeutic candidates are categorized into early, mid, and late-stage development.

Active and inactive projects, including paused or discontinued treatments.

Classify new drugs under development by stage, route of administration, mechanism of action, monotherapy/combination therapy, and molecule type.

Details of collaborations, licensing agreements, and funding that will shape the future of the Influenza A market.

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Over-the-counter medications for influenza A

XOFLUZA (baloxavir marboxil) – Genentech/Roche

RAPIVAB (Peramivir Injection) – BioCryst Pharmaceuticals

FLUZONE QUADRIVALENT – サノフィ

Emerging Therapeutics for Influenza A

CD388 – Cidara Therapeutics

SAB-176 – SAB biopharmaceutical

VIR-2482 – For biotech

Major companies in influenza A

Several companies, including Cidara Therapeutics, SAB Biotherapeutics, FluGen, Moderna, Vir Biotechnology, and Vaxart, are at the forefront of developing influenza A treatments.

Among them, Arcutis Biotherapeutics Inc. is moving one of the most advanced drug candidates through Phase II clinical trials.

DelveInsight's reports cover three or more products across various stages of clinical development.

Late stage (Phase III)

Mid-term (Phase II)

Early Stage (Phase I)

Preclinical and discovery stage candidates

Discontinued and inactive candidates

Therapeutic Assessment (ROA) by Route of Administration

Influenza A pipeline drugs are segmented by ROA as follows:

Intravenous

Subcutaneous

Oral